Chemical disarming of isoniazid resistance inMycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Simultaneous ethambutol & isoniazid resistance in clinical isolates of Mycobacterium tuberculosis.
BACKGROUND & OBJECTIVE There is a need to understand the nature of drug resistance patterns and predictors of emergence of drug resistance in Mycobacterium tuberculosis. There could be common factors/mechanisms for resistance to the drugs, isoniazid and ethambutol, both acting on cell wall. The present study was conducted to analyze the antimycobacterial susceptibility patterns of M. tuberculos...
متن کاملDevelopment of multidrug resistance during treatment of isoniazid-resistant tuberculosis.
Several treatment regimens have been recommended for the treatment of isoniazid-resistant tuberculosis (TB). However, an optimal regimen and duration for this treatment remains a matter of some controversy. Here, we would like to share our experience in a case of pulmonary TB with acquired multidrug resistance, during a 12-month treatment of isoniazid-resistant TB with rifampin and ethambutol, ...
متن کاملIsoniazid resistance without a loss of fitness in Mycobacterium tuberculosis
The emergence of multi- and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) has intensified the critical public health implications of this global disease. The fitness of Mycobacterium tuberculosis (M.tb.) strains exhibiting MDR and XDR phenotypes is of fundamental importance in predicting whether the MDR-/XDR-TB epidemic will be sustained across the human population. ...
متن کاملThe molecular basis of isoniazid resistance in Mycobacterium tuberculosis.
Isoniazid, the hydrazide of isonicotinic acid, was synthesized for the first time in 1912 by two Czech scientists, but its powerful antituberculous activity was detected only in 1951, and the discovery of isoniazid was a milestone in the chemotherapy of tuberculosis. Its activity is excellent against species of the Mycobacterium tuberculosis complex (M. tuberculosis, Mycobacterium bovis, Mycoba...
متن کاملResistance to rifampicin and isoniazid in strains of Mycobacterium tuberculosis.
Drug susceptibility studies on strains of Mycobacterium tuberculosis isolated from widely different populations of patients and tested by two different techniques indicated that all 55 strains resistant to rifampicin were also resistant to isoniazid, while many strains resistant to isoniazid were found to be susceptible to rifampicin. This observation, which has as yet unknown laboratory and cl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1818009116